Invention Grant
- Patent Title: Method for obtaining a stable gel of hyaluronic acid and of a free form of vitamin C and/or a salt thereof
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Application No.: US14786721Application Date: 2014-04-23
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Publication No.: US09669007B2Publication Date: 2017-06-06
- Inventor: Alfred Marchal , Jerome Cabou , Damien Lacroix , Jacques Dubois
- Applicant: AURIGA INTERNATIONAL
- Applicant Address: BE Waterloo
- Assignee: Auriga International
- Current Assignee: Auriga International
- Current Assignee Address: BE Waterloo
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: BE2013/0295 20130426
- International Application: PCT/EP2014/058229 WO 20140423
- International Announcement: WO2014/173941 WO 20141030
- Main IPC: A61K31/375
- IPC: A61K31/375 ; A61K8/67 ; A61K8/73 ; A61Q19/08 ; A61K9/00 ; A61K8/04 ; A61K8/19 ; A61K8/23 ; A61K31/728 ; A61K47/02 ; A61K9/06 ; A61K45/06 ; A61K47/36 ; A61Q19/00

Abstract:
The invention relates to a process for producing an aqueous gel comprising hyaluronic acid, vitamin C, and a stabilizing agent selected from the metabisulfites. According to the invention, such a process comprises the steps of a) preparing a mixture comprising crosslinked or non-crosslinked hyaluronic acid and/or a salt thereof with a molar mass of between 1000 Da and 10 MDa, from 0.1 to 20.0% by weight of vitamin C in its acid form, or its equivalent in ascorbate derived from a vitamin C salt, from 0.01 to 1.00% by weight of a stabilizing agent selected from the metabisulfites, and an aqueous solution added so that the hyaluronic acid content is between 0.01 and 100 mg/ml, so as to form a hydrogel, and b) degassing the mixture before the hydrogel being formed is completely swollen.
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