Invention Grant
- Patent Title: Neprilysin inhibitors
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Application No.: US14792810Application Date: 2015-07-07
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Publication No.: US09670140B2Publication Date: 2017-06-06
- Inventor: Adam D. Hughes
- Applicant: Adam D. Hughes
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Wendy Petka
- Main IPC: C07C229/22
- IPC: C07C229/22 ; C07C271/22 ; C07D249/18 ; A61K31/4192 ; A61K45/06 ; C07D231/20 ; A61K31/415 ; C07D405/12 ; A61K31/4155 ; A61K31/4439 ; C07D401/04 ; C07D405/14 ; C07D231/14 ; C07D261/18 ; A61K31/42 ; C07D249/04 ; C07D249/12 ; A61K31/4196 ; C07D257/04 ; A61K31/41 ; A61K31/675 ; C07F9/6503 ; C07D231/18 ; C07D253/08 ; C07D207/26 ; C07D263/38

Abstract:
In one aspect, the invention relates to compounds having the formula XII: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
Public/Granted literature
- US20160002148A1 NEPRILYSIN INHIBITORS Public/Granted day:2016-01-07
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