Invention Grant
- Patent Title: SIK inhibitor for use in a method of treating an inflammatory and/or immune disorder
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Application No.: US14385077Application Date: 2013-03-13
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Publication No.: US09670165B2Publication Date: 2017-06-06
- Inventor: Philip Cohen , Kristopher Clark , Hwan Geun Choi , Nathanael Gray
- Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE , DANA-FARBER CANCER INSTITUTE, INC.
- Applicant Address: US MA Boston GB Dundee
- Assignee: Dana-Farber Cancer Institute, Inc.,University Court of the University of Dundee
- Current Assignee: Dana-Farber Cancer Institute, Inc.,University Court of the University of Dundee
- Current Assignee Address: US MA Boston GB Dundee
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: GB1204384.0 20120313
- International Application: PCT/GB2013/050618 WO 20130313
- International Announcement: WO2013/136070 WO 20130919
- Main IPC: C07D239/48
- IPC: C07D239/48 ; C07D403/12 ; A61K31/505 ; A61K31/506 ; A61K31/519 ; A61K31/5377 ; C07D413/12 ; C07D487/04
Abstract:
The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.
Public/Granted literature
- US20150045370A1 SIK INHIBITOR FOR USE IN A METHOD OF TREATING AN INFLAMMATORY AND/OR IMMUNE DISORDER Public/Granted day:2015-02-12
Information query
