Invention Grant
- Patent Title: Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
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Application No.: US14977918Application Date: 2015-12-22
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Publication No.: US09670204B2Publication Date: 2017-06-06
- Inventor: Nicolas Desroy , Bertrand Heckmann , Reginald Christophe Xavier Brys , Agnès Marie Joncour , Christophe Peixoto , Xavier Marie Bock
- Applicant: Galapagos NV
- Applicant Address: BE Mechelen
- Assignee: GALAPAGOS NV
- Current Assignee: GALAPAGOS NV
- Current Assignee Address: BE Mechelen
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Main IPC: C07D401/04
- IPC: C07D401/04 ; A61K31/4353 ; C07D471/04 ; A61K31/437 ; A61K31/496 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61K31/444 ; A61K31/4545 ; A61K45/06

Abstract:
The present invention discloses compounds according to Formula I: Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.
Public/Granted literature
- US20160244443A1 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS Public/Granted day:2016-08-25
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