Invention Grant
- Patent Title: Modulation of the VPS10p-domain receptor family for the treatment of mental and behavioural disorders
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Application No.: US14192310Application Date: 2014-02-27
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Publication No.: US09670263B2Publication Date: 2017-06-06
- Inventor: Simon Glerup Pedersen , Ulrich Bolcho , Kimmo Jensen , Anders Nykjaer
- Applicant: Simon Glerup Pedersen , Ulrich Bolcho , Kimmo Jensen , Anders Nykjaer
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: AuerbachSchrot LLC
- Agent Jeffrey I. Auerbach
- Priority: DK200801825 20081219
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K14/705 ; A61K38/12 ; A61K38/17 ; A61K38/18 ; G01N33/94 ; A61K45/06 ; C07K14/47
Abstract:
The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3, in an animal and methods for preparation of a medicament for the treatment of mental and behavioral disorders. The modulation is carried out by inhibiting or promoting the binding of ligands to the Vps10p-domain receptor. In vitro and in vivo methods for screening for agents capable of modulation of said Vps10p-domain receptor activity are also provided. The invention furthermore relates to methods of altering expression of said receptors in vivo.
Public/Granted literature
- US20140242087A1 Modulation Of The VPS10p-Domain Receptor Family For The Treatment Of Mental And Behavioural Disorders Public/Granted day:2014-08-28
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