Invention Grant
- Patent Title: Method and composition for crystallizing G protein-coupled receptors
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Application No.: US14684217Application Date: 2015-04-10
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Publication No.: US09670266B2Publication Date: 2017-06-06
- Inventor: Brian Kobilka , Daniel Rosenbaum
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Bozicevic, Field & Francis LLP
- Agent James S. Keddie
- Main IPC: G06F3/048
- IPC: G06F3/048 ; G06F17/50 ; C07K14/72 ; C07K14/705 ; C12N9/36
Abstract:
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.
Public/Granted literature
- US20150210751A1 Method and Composition for Crystallizing G Protein-Coupled Receptors Public/Granted day:2015-07-30
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