Invention Grant
- Patent Title: Sequences directed against hepatocyte growth factor (HGF) and polypeptides comprising the same for the treatment of cancers and/or tumors
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Application No.: US14373375Application Date: 2013-01-16
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Publication No.: US09670275B2Publication Date: 2017-06-06
- Inventor: Joost Alexander Kolkman , Hilde Adi Pierrette Revets , Jo Vercammen , Augustinus Antonius Maria Silvester van Dongen
- Applicant: Ablynx N.V.
- Applicant Address: BE Zwijnaarde
- Assignee: Ablynx N.V.
- Current Assignee: Ablynx N.V.
- Current Assignee Address: BE Zwijnaarde
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/EP2013/050724 WO 20130116
- International Announcement: WO2013/110531 WO 20130801
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/22 ; C07K16/28 ; G01N33/574 ; A61K39/00
Abstract:
The present invention relates to biological materials against HGF and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the biological materials of the present invention inhibit binding of HGF to its receptor c-Met.
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