Embodiments of the present invention provide a solution for managing inter-domain resource allocation in a Peripheral Component Interconnect-Express (PCIe) network. One processor among a plurality of link processors is elected as a management processor. The management processor obtains information about available resources of PCIe network. When a resource request from a request processor is received, the management processor allocates a resource of the available resources to the requesting processor. The management processor instructs one or more link processors to program one or more inter-domain NTBs through which the traffic between the allocated resource and the requesting processor is going to flow according to the memory address information of the allocated resource, to allow cross-domain resource access between the requesting processor and the allocated resource.