A system and method for data deduplication includes a first computer device that determines duplicacy of a data item. If the data item is not a duplicate, the first computer device transmits a request to add an entry for the data item in a deduplication table of a deduplication database. The database adds the entry for the data item while enforcing uniqueness of data across one or more data fields of the deduplication table, where, in enforcing the uniqueness, the database denies an attempt by the second device to add an entry in the deduplication table for the same data item.