A method includes forming a protection material over a conductive structure, an opening over the structure is partially filled with a first electrode material to form a first electrode; a resistance variable layer and a second electrode material are also formed in the opening. The second electrode material and the resistance variable layer are patterned to form a memory element. The method includes forming an interlayer dielectric over the memory element and the periphery region of the substrate and disposing contacts in the interlayer dielectric.