Embodiments relate to systems and methods for managing third-party application programming interfaces in a collaboration space. A collaboration space, such as a wiki site, can host a set of collaboration tools and resources, including, for example, content tools, communication tools, and other resources for the users of the space. The collaboration space can also incorporate and expose a set of application programming interfaces, such as command and data-passing structures to permit users to invoke third-party applications and/or services from within the wiki site or other collaboration space. The set of applications/services be hosted on a remote server or co-hosted on the collaboration server, and can include, for instance, database, spreadsheet, media content, or other applications or services. The invoked applications/services can return data to the requesting user via the collaboration space. Users can subscribe to different applications and/or services available via the collaboration space.