Systems and methods are provided for generating high-dynamic range images. In particular, a signal-to-noise (SNR) ratio objective associated with an imaging platform configured to capture one or more images of a region of interest can be determined. The SNR objective can specify a desired signal-to-noise ratio behavior as a function of a brightness of the region of interest. An exposure profile associated with the imaging platform can then be determined based at least in part on the SNR objective. Data indicative of a plurality of image frames, each depicting at least a portion of the region of interest, can then be obtained. The plurality of image frames being captured by the imaging platform in accordance with the exposure profile.