A communication system includes a headset including a microphone and an audio speaker installed on the headset, the headset including an RF transceiver configured to perform wireless communication with a two-way radio having a push-to-talk communication channel. The RF transceiver is further configured to perform wireless communication with an information handling system. The headset includes processing electronics configured to process an input signal from the microphone and output a first processed signal to the RF transceiver and to process an input signal from the RF transceiver and output a second processed signal to the speaker. A remote control unit is configured to perform wireless communication with the headset, the remote control unit including a remote control unit interface disposed thereon for selectively configuring the headset to function as an audio interface for the push-to-talk communication channel and an audio interface for the information handling system.