Invention Grant
- Patent Title: MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer
-
Application No.: US14615416Application Date: 2015-02-05
-
Publication No.: US09675620B2Publication Date: 2017-06-13
- Inventor: Jean C. Shih , Florence M. Hofman , Thomas C. Chen
- Applicant: University of Southern California
- Applicant Address: US CA Los Angeles
- Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
- Current Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
- Current Assignee Address: US CA Los Angeles
- Agency: DLA Piper LLP (US)
- Main IPC: A61K49/16
- IPC: A61K49/16 ; A61K31/5375 ; A61K31/4188 ; A61K31/4045 ; C07D209/24 ; A61K31/137 ; A61K45/06 ; A61K31/352 ; A61K31/357 ; A61K31/381 ; C12N15/113 ; A61K31/135 ; A61K31/138 ; A61K31/15 ; A61K31/366 ; A61K31/405 ; A61K31/495
Abstract:
A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
Public/Granted literature
- US20160339034A9 MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer Public/Granted day:2016-11-24
Information query
