Reconfigurable payload systems (RPS) and methods of configuring and using the same are disclosed that may be employed to enable external aircraft payloads to be rapidly interchanged or swapped out together with associated internal equipment within a given aircraft so as to modify or change payload capability of the aircraft, e.g., to meet a particular mission and/or to enable use of future payload types as they are developed. The RPS and associated methods may be implemented to allow multiple different payload systems to be swapped in and out on a given aircraft as required based on needs for a given mission.