Invention Grant
- Patent Title: Method for producing indanone derivatives
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Application No.: US14241964Application Date: 2012-08-24
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Publication No.: US09676691B2Publication Date: 2017-06-13
- Inventor: Oskar Koch , Dietmar Schatkowski , William Johncock , Christel Jahnke , Karl-Georg Fahlbusch
- Applicant: Oskar Koch , Dietmar Schatkowski , William Johncock , Christel Jahnke , Karl-Georg Fahlbusch
- Applicant Address: DE Holzminden
- Assignee: SYMRISE AG
- Current Assignee: SYMRISE AG
- Current Assignee Address: DE Holzminden
- Agency: Polsinelli PC
- Priority: EP11179791 20110901
- International Application: PCT/EP2012/066502 WO 20120824
- International Announcement: WO2013/030110 WO 20130307
- Main IPC: C07C45/65
- IPC: C07C45/65 ; C07C49/755 ; A61K8/35 ; A61Q17/04 ; A61Q19/00 ; C07C45/74 ; C07C45/72

Abstract:
A method is described for producing a compound having the formula (I) or an admixture comprising a compound having the formula (I), having the following steps: dissolving an indanone having the formula (II) in a solvent or in an admixture which contains a solvent, the solvent being selected from the group of solvents which form an azeotrope with water, converting the indanone having the formula (II) with an aromatic aldehyde having the formula (III) in the presence of at least one organic base, according to the drawing: where R1 and R2 independently of each other signify hydrogen or a branched or unbranched alkyl group having from 1 to 12 carbon atoms and where R3, R4, R5, R6, R7, R8, R9, R10 and R11 independently of each other signify hydrogen, hydroxy or a branched or unbranched alkyl or alkoxy group having from 1 to 12 carbon atoms and removing water formed from the reaction admixture during the conversion. An admixture comprising a compound of the formula (I) and other components is further described.
Public/Granted literature
- US20150071866A1 METHOD FOR PRODUCING INDANONE DERIVATIVES Public/Granted day:2015-03-12
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