Invention Grant
- Patent Title: Controlled HNO release through intramolecular cyclization-elimination
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Application No.: US14439800Application Date: 2013-10-30
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Publication No.: US09676708B2Publication Date: 2017-06-13
- Inventor: John P. Toscano , Art D. Sutton
- Applicant: The Johns Hopkins University
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Byrne Poh LLP
- Agent Nina R. Horan
- International Application: PCT/US2013/067558 WO 20131030
- International Announcement: WO2014/070919 WO 20140508
- Main IPC: C07C311/48
- IPC: C07C311/48 ; A61K31/4152 ; A61K31/27 ; A61K45/06 ; A61K31/265
Abstract:
Protected HNO donors designed to undergo non-enzymatic release at neutral pH via an intramolecular cyclization-elimination are disclosed. The rate of cyclization, and therefore HNO release, can be controlled by substituents and chain length. Thus, biologically useful HNO donors having tunable HNO release rates are provided.
Public/Granted literature
- US20150291519A1 CONTROLLED HNO RELEASE THROUGH INTRAMOLECULAR CYCLIZATION-ELIMINATION Public/Granted day:2015-10-15
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