Invention Grant
- Patent Title: Oligopeptidic compounds and uses thereof
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Application No.: US14493728Application Date: 2014-09-23
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Publication No.: US09676822B2Publication Date: 2017-06-13
- Inventor: Marit Otterlei , Per Arne Aas , Emadoldin Feyzi
- Applicant: APIM THERAPEUTICS AS
- Applicant Address: NO Trondheim
- Assignee: APIM THERAPEUTICS AS
- Current Assignee: APIM THERAPEUTICS AS
- Current Assignee Address: NO Trondheim
- Agency: Knobbe, Martens, Olson & Bear LLP
- Priority: GB0803352.4 20080222
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/16 ; C07K7/04 ; C07K9/00 ; C07K14/00 ; C07K14/47 ; G01N33/68 ; A61K38/00

Abstract:
Disclosed is an oligopeptidic compound capable of interacting with proliferating cell nuclear antigen (PCNA), wherein the compound comprises a PCNA interacting motif which is: (SEQ ID NO. 28) [K/R]-[F/Y/W]-[L/I/V/A/M]-[L/I/V/A/M]-[K/R]; wherein the oligopeptidic compound has 9-70 subunits and comprises at least one signal sequence, wherein the signal sequence is a nuclear localization signal sequence and/or a cell penetrating signal sequence and wherein in said compound a PCNA interacting motif is N-terminal to a signal sequence. Also disclosed are methods of treatment of a disorder or condition where it is desirable to inhibit the growth of cells, or a method of treatment which involves cytostatic therapy, or a method of treatment of inflammation said method comprising administering the oligopeptidic compound to a subject in need thereof.
Public/Granted literature
- US20150017232A1 OLIGOPEPTIDIC COMPOUNDS AND USES THEREOF Public/Granted day:2015-01-15
Information query
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