- Patent Title: cDNA-derived nucleic acids encoding red-shifted channelrhodopsins
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Application No.: US14789702Application Date: 2015-07-01
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Publication No.: US09676836B2Publication Date: 2017-06-13
- Inventor: John Lee Spudich , Elena G. Govorunova , Oleg A. Sineshchekov
- Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TX Austin
- Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TX Austin
- Agency: Conley Rose, P.C.
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C12N1/16 ; C12N1/20 ; C12N5/04 ; C12N5/071 ; C12N5/079 ; C12N15/00 ; C12N15/09 ; C07K14/405
Abstract:
Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo.
Public/Granted literature
- US20150299291A1 cDNA-DERIVED NUCLEIC ACIDS ENCODING RED-SHIFTED CHANNELRHODOPSINS Public/Granted day:2015-10-22
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