A method of making a pharmaceutical compounding system having automated micro-dosing capability, the method comprising identifying a technology that can facilitate controlled and automated dispensation of material, such that the dispensation does not necessitate augmentation of material by mass or volume to aid with measurement or manipulation in order to achieve a level of dispensing precision that can be medically acceptable for at least some drug substances; and adapting the technology for prescription-specific operability for producing customized drug products, the adapting comprising configuring the technology for production of pills in prescribed numbers with prescribed drugs at prescribed doses via distinct runs for respective patients.