Invention Grant
- Patent Title: Functional polymer film-coated particle having high drug content, tablet containing same, and methods for production thereof
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Application No.: US14889657Application Date: 2013-05-08
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Publication No.: US09693965B2Publication Date: 2017-07-04
- Inventor: Tomohiro Hayashida , Junji Yamazaki , Yoshio Nakano , Masaya Hizaki , Naotoshi Kinoshita
- Applicant: ZENSEI PHARMACEUTICAL INDUSTRIES CO., LTD. , POWREX CORPORATION
- Applicant Address: JP Hyogo JP Osaka
- Assignee: POWEREX CORPORATION,ZENSEI PHARMACUETICAL INDUSTRIES CO., LTD.
- Current Assignee: POWEREX CORPORATION,ZENSEI PHARMACUETICAL INDUSTRIES CO., LTD.
- Current Assignee Address: JP Hyogo JP Osaka
- Agency: Millen, White, Zelano and Branigan, P.C.
- International Application: PCT/JP2013/062890 WO 20130508
- International Announcement: WO2014/181390 WO 20141113
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/48 ; A61K9/20 ; A61K31/137 ; A61K31/522 ; A61K9/00 ; A61K9/50 ; B01J2/00 ; B01J2/16 ; A61K9/16

Abstract:
Provided are functional drug-containing particles which can be compressed into tablets and in particular, to orally disintegrating tablets by employing any of a dry molding method, a wet molding method, or a humidifying drying method. The functional drug-containing particles comprise substantially spherical drug-containing particles essentially including drug and a binder, the functional drug-containing particles including a functional polymer film selected from the group consisting of an enteric film, a release control film, and a bitter taste masking film, an average particle diameter of said functional drug-containing particles being 400 μm or less, a particle diameter ratio D90/D10 of the functional drug-containing particles with respect to particle size distribution calculated on a volumetric basis being 1.65 or more, or a coefficient of variation in particle diameters being 24% or more.
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