The present disclosure relates generally to fume hoods, and more particularly to systems and methods for controlling a fume hood airflow using an image (e.g., an optical image, an acoustic image, etc.) of a fume hood opening. A system for controlling a fume hood may include an image capture sensor, a configurator and a controller. The image capture sensor may be positioned to have a field of view that includes at least a portion of a fume hood opening, and may be configured to capture an image that includes at least part of the fume hood opening and/or a person working at the hood. The controller may then provide a control signal to a ventilation device for providing a desired airflow in the fume hood. The control signal provided to the ventilation device may depending on the current size of the fume hood opening as captured by the image capture sensor.