A vehicle rear portion structure has: a suspension structural portion that overlaps a rear side member as seen in a vehicle plan view; an inlet pipe that passes-through between the rear side member and the suspension structural portion; and a pipe protecting portion that is provided at a position overlapping the rear side member and the suspension structural portion in a vehicle plan view, and a length in a vehicle vertical direction of the pipe protecting portion is set to be longer than an outer diameter of the inlet pipe, and rigidity, with respect to load from a vehicle lower side, of the pipe protecting portion is set to be higher than that of the inlet pipe.