Invention Grant
- Patent Title: Oligooxopiperazines for p53 reactivation
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Application No.: US14160037Application Date: 2014-01-21
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Publication No.: US09695153B2Publication Date: 2017-07-04
- Inventor: Paramjit S. Arora , Quintin Pan , Anna Mapp
- Applicant: New York University , The Ohio State University Research Foundation , The Regents of the University of Michigan
- Applicant Address: US NY New York US OH Columbus US MI Ann Arbor
- Assignee: New York University,The Ohio State University Research Foundation,The Regents of the University of Michigan
- Current Assignee: New York University,The Ohio State University Research Foundation,The Regents of the University of Michigan
- Current Assignee Address: US NY New York US OH Columbus US MI Ann Arbor
- Agency: LeClairRyan, a Professional Corporation
- Main IPC: C07D403/06
- IPC: C07D403/06 ; A61K31/496 ; A61K45/06
Abstract:
The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix αB of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1α. Methods of using the oligooxopiperazines are also disclosed. Exemplary oligooxopiperazines include those of Formula I below (wherein A, R1, R2, R3, R4, and B are as defined herein).
Public/Granted literature
- US20140205655A1 OLIGOOXOPIPERAZINES FOR p53 REACTIVATION Public/Granted day:2014-07-24
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