Invention Grant
- Patent Title: Substituted 7-azabicycles and their use as orexin receptor modulators
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Application No.: US15262882Application Date: 2016-09-12
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Publication No.: US09695183B2Publication Date: 2017-07-04
- Inventor: Heather R. Coate , Curt A. Dvorak , Terry P. Lebold , Cathy Preville , Brock T. Shireman
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: JANSSEN PHARMACEUTICA NV
- Current Assignee: JANSSEN PHARMACEUTICA NV
- Current Assignee Address: BE Beerse
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/506 ; A61K31/444 ; A61K31/4439 ; A61K31/497 ; A61K31/498 ; A61K31/4709 ; A61K31/501 ; A61K31/4725 ; A61K31/4985 ; A61K31/496 ; A61K31/423 ; C07D487/08 ; C07D513/04 ; C07D471/04 ; C07D519/00

Abstract:
The present invention is directed to compounds of Formula I: wherein A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl, or indazolyl; R1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl, or dialkylamino; R2 is H, alkyl, alkoxy, hydroxyalkylene, or halo; Z is NH, N-alkyl, or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinazolinyl, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, or triazolopyrazinyl, optionally substituted with a one or two substituents independently selected from the group consisting of alkyl, alkoxy, or halo; and n is 0 or 1. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
Public/Granted literature
- US20160376280A1 Substituted 7-Azabicycles And Their Use As Orexin Receptor Modulators Public/Granted day:2016-12-29
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