Invention Grant
- Patent Title: Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
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Application No.: US14106687Application Date: 2013-12-13
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Publication No.: US09695212B2Publication Date: 2017-07-04
- Inventor: Thomas W. Dubensky, Jr. , David B. Kanne , Meredith Lai Ling Leong , Edward Emile Lemmens , Laura Hix Glickman
- Applicant: Aduro Biotech, Inc.
- Applicant Address: US CA Berkeley
- Assignee: Aduro Biotech, Inc.
- Current Assignee: Aduro Biotech, Inc.
- Current Assignee Address: US CA Berkeley
- Agency: Acuity Law Group, P.C.
- Agent Michael A. Whittaker
- Main IPC: A61K31/7084
- IPC: A61K31/7084 ; C07H21/02 ; C07H21/04 ; C07H19/213 ; C07H21/00 ; A61K39/00 ; A61K39/02 ; A61K39/12 ; A61K39/39
Abstract:
It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers.
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