The present invention relates generally to the field of diarrheal diseases caused by intestinal spirochaetes. Specifically, the invention relates to the prevention and/or treatment of infections with B. hyodysenteriae. In one aspect, the invention relates to a novel recombinant polypeptide, wherein said polypeptide may preferably be combined with one or more further recombinant polypeptides. In a further aspect, an immunogenic composition containing said recombinant polypeptide(s) is provided for use in a method for treating or preventing clinical signs caused by Brachyspira hyodysenteriae.