Invention Grant
- Patent Title: Broadly neutralizing HIV-1 VRC07 antibodies that bind to the CD4-binding site of the envelope protein
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Application No.: US14363740Application Date: 2012-12-10
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Publication No.: US09695230B2Publication Date: 2017-07-04
- Inventor: Peter D. Kwong , Gary J. Nabel , Rebecca S. Rudicell , John Mascola , Mark Connors , Ivelin Georgiev , Jiang Zhu , Young Do Kwon , Tongqing Zhou , Yongping Yang , Baoshan Zhang , Gwo-Yu Chuang , Xueling Wu , Zhi-yong Yang , Wei Shi
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2012/068827 WO 20121210
- International Announcement: WO2013/086533 WO 20130613
- Main IPC: C07K16/10
- IPC: C07K16/10 ; G01N33/569 ; A61K39/42 ; A61K45/06
Abstract:
Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
Public/Granted literature
- US20140322163A1 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE Public/Granted day:2014-10-30
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