Invention Grant
- Patent Title: Screening method for inhibitors of binding of zBR7R1 to CD155
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Application No.: US15069065Application Date: 2016-03-14
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Publication No.: US09695238B2Publication Date: 2017-07-04
- Inventor: Zeren Gao , Steven D. Levin , Janine M. Bilsborough , James W. West , Cameron S. Brandt , Eric M. Chadwick
- Applicant: ZYMOGENETICS, INC.
- Agent Gregory R. Bellomy
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/47 ; C07K14/705 ; G01N33/50 ; C12Q1/66 ; G01N33/569 ; A61K38/00 ; A61K39/00
Abstract:
The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
Public/Granted literature
- US20160185863A1 COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES Public/Granted day:2016-06-30
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