Invention Grant
- Patent Title: Pharmaceutical compositions with resistance to soluble CEA
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Application No.: US13740358Application Date: 2013-01-14
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Publication No.: US09695250B2Publication Date: 2017-07-04
- Inventor: Ralf Lutterbüse , Petra Fluhr , Evelyne Schaller , Doris Rau , Susanne Mangold , Peter Kufer , Alexander Murr , Tobias Raum , Monika Wissinger
- Applicant: AMGEN RESEARCH (MUNICH) GMBH
- Applicant Address: DE Munich
- Assignee: AMGEN RESEARCH (MUNICH) GMBH
- Current Assignee: AMGEN RESEARCH (MUNICH) GMBH
- Current Assignee Address: DE Munich
- Agency: Marshall, Gerstein & Borun LLP
- Priority: EP05028064 20051221
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/46 ; A61K45/06 ; C07K16/28 ; C07K16/30 ; A61K39/395

Abstract:
The present disclosure relates to a bispecific single chain antibody which has a first binding domain specifically binding to human CD3, and a second binding domain specifically binding to human CEA, where the second binding domain comprises at least a part of the CDR-H3 or the complete CDR-H3 of murine monoclonal antibody A5B7, a pharmaceutical composition comprising the bispecific single chain antibody, and methods for the treatment of an epithelial tumor in a human with the pharmaceutical compositions containing the bispecific single chain antibody. Furthermore, processes for the production of the pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CEA antigen are disclosed.
Public/Granted literature
- US20130273050A1 PHARMACEUTICAL COMPOSITIONS WITH RESISTANCE TO SOLUBLE CEA Public/Granted day:2013-10-17
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