- Patent Title: Activatable cell penetrating peptides with quenched fluorophores
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Application No.: US13566913Application Date: 2012-08-03
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Publication No.: US09695251B2Publication Date: 2017-07-04
- Inventor: Roger Y. Tsien , Tao Jiang , Elamprakash N. Savariar
- Applicant: Roger Y. Tsien , Tao Jiang , Elamprakash N. Savariar
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; C07K19/00 ; A61K49/00 ; A61K41/00 ; A61K47/48 ; A61K49/08 ; A61K49/14 ; A61K51/08 ; C07K14/47
Abstract:
The invention provides compositions useful as molecular probes. In particular, the invention provides activatable cell penetrating peptides comprising a fluorescence donor and a fluorescence acceptor. Exemplary fluorescence donors and fluorescence acceptors include compounds derived from cyanine. Also provided are ratiometric, multispectral, and excitation lifetime imaging methods for detecting the molecular probes provided herein.
Public/Granted literature
- US20130078188A1 ACTIVATABLE CELL PENETRATING PEPTIDES WITH QUENCHED FLUOROPHORES Public/Granted day:2013-03-28
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