Invention Grant
- Patent Title: Furin-knockdown bi-functional RNA
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Application No.: US14844912Application Date: 2015-09-03
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Publication No.: US09695422B2Publication Date: 2017-07-04
- Inventor: John J. Nemunaitis , Neil Senzer , Phillip B. Maples , Donald Rao
- Applicant: GRADALIS, INC.
- Applicant Address: US TX Dallas
- Assignee: GRADALIS, INC.
- Current Assignee: GRADALIS, INC.
- Current Assignee Address: US TX Dallas
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C07H21/04 ; C07K1/00 ; C12N15/113 ; A61K38/21 ; C12N15/85 ; C07K14/535 ; A61K38/19 ; A61K48/00
Abstract:
Compositions and methods to attenuate the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs is described herein. The bi-functional shRNAs of the present invention knocks down the expression of furin in cancer cells to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
Public/Granted literature
- US20150368651A1 FURIN-KNOCKDOWN BI-FUNCTIONAL RNA Public/Granted day:2015-12-24
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