Invention Grant
- Patent Title: Vector for the selective silencing of a gene in astrocytes
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Application No.: US14403722Application Date: 2013-05-24
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Publication No.: US09695443B2Publication Date: 2017-07-04
- Inventor: Nicole Deglon
- Applicant: Commissariat a I'Energie Atomique et aux Energies Alternatives
- Applicant Address: FR Paris
- Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
- Current Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
- Current Assignee Address: FR Paris
- Agency: Morgan, Lewis & Bockius LLP
- Priority: EP12305588 20120525; EP12305828 20120710
- International Application: PCT/IB2013/054308 WO 20130524
- International Announcement: WO2013/175446 WO 20131128
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/86
Abstract:
The present invention relates to a viral vector for silencing a gene specifically in astrocytes comprising: —an astrocyte-specific viral envelope protein, —a first nucleic acid sequence encoding a transcription activator and at least one target sequence of a neuron-specific miR under the control of an astrocyte-specific promoter, and—a second nucleic acid sequence encoding a RNA for silencing the gene under the control of a promoter inducible by the transcription activator.
Public/Granted literature
- US20150159171A1 VECTOR FOR THE SELECTIVE SILENCING OF A GENE IN ASTROCYTES Public/Granted day:2015-06-11
Information query
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