A system and method of transposed storage in RAID arrays includes a storage manager with an interface for receiving storage requests associated with multi-segment blocks stored in a storage array, a controller for processing the received storage requests and controlling the storage manager, and a write request handler. The storage array includes a plurality of storage devices for which consecutive logical addresses are assigned to different ones of the storage devices. The write request handler is configured to process block write requests and send segment write requests to the storage array based on the write requests so that each segment of a given multi-segment block is written to a single respective one of the storage devices in the storage array. In some embodiments, the storage manager further includes a read request handler configured to determine logical addresses of requested segments and send segment read requests to the storage array.