The present invention relates to a system that manages security of one or more computer systems and/or one or more different types of I/O channels such as USB, Ethernet, SATA, and SAS. According to certain aspects, the management system is distributed. That is, a central management system and computer subsystems are physically distributed within one or more geographical areas, and communicate with each other by passing messages through a computer network. According to certain additional aspects, the configuration and/or security functions performed by methods and apparatuses according to the invention can be logically transparent to the upstream host and to the downstream device.