Systems, methods, and instrumentalities are disclosed relating to intra prediction of a video signal based on mode-dependent subsampling. A block of coefficients associated with a first sub block of a video block, one or more blocks of coefficients associated with one or more remaining sub blocks of the video block, and an indication of a prediction mode for the video block may be received. One or more interpolating techniques, a predicted first sub block, and the predicted sub blocks of the one or more remaining sub blocks may be determined. A reconstructed first sub block and one or more reconstructed remaining sub blocks may be generated. A reconstructed video block may be formed based on the prediction mode, the reconstructed first sub block, and the one or more reconstructed remaining sub blocks.