Invention Grant
- Patent Title: Metabolic therapy for oxidative stress in the brain through targeted neuronal catabolism of N-acetyl-aspartic acid
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Application No.: US13906171Application Date: 2013-05-30
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Publication No.: US09700604B2Publication Date: 2017-07-11
- Inventor: Paola Leone , Jeremy Francis
- Applicant: University of Medicine and Dentistry of New Jersey
- Applicant Address: US NJ Glassboro
- Assignee: Rowan University
- Current Assignee: Rowan University
- Current Assignee Address: US NJ Glassboro
- Agency: Fox Rothschild LLP
- Main IPC: A61K38/50
- IPC: A61K38/50 ; C12N15/86 ; A61K38/52 ; A61K35/30
Abstract:
The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.
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