The invention relates to a method and control system to control the speed of a centrifugal compressor operating within a vacuum pressure swing adsorption process to avoid an operation at which surge can occur and directly driven by an electric motor that is in turn controlled by a variable frequency drive. The claimed method determines the optimal speed for operation of the compressor along a peak efficiency operating line of a compressor map thereof. Speed of the compressor is adjusted by a feed back speed multiplier when the flow or other parameter referable to flow through the compressor is below a minimum and a feed forward multiplier during evacuation and evacuation with purge steps that multiplies the feed back multiplier to increase speed of the compressor and thereby avoid surge.