Methods and systems for crest factor reduction may comprise generating an original waveform to be amplified by a programmable gain amplifier (PGA); generating a distortion signal utilizing a PGA model that predicts an output signal of the PGA based on the original waveform; generating an error signal by subtracting out the original waveform from the distortion signal; filtering the generated error signal; generating a conditioned waveform with crest factor reduced from that of the original waveform by adding the filtered error signal to the original waveform; and amplifying the conditioned waveform. The crest factor of the original waveform may be reduced based on spectral mask requirements. The generating of the conditioned waveform may be iterated. The distortion signal may be generated based on a predistortion model. A signal may be fed back from an output of the PGA to the predistortion model, which may be dynamically configured.