Mechanisms, in a data processing system comprising an input/output subsystem implementing an industry standard optical bus, for handling a failure of an optical channel in an optical bus are provided. The mechanisms detect, by failure detection logic of the input/output (I/O) subsystem, failure of an optical channel of the optical bus. The mechanisms send, by a controller of the I/O subsystem, a control signal to channel routing logic of the I/O subsystem to control a routing of data signals between active bus lanes of the data processing system and optical channels of the optical bus in response to detecting the failure of the optical channel. The mechanisms control, by the channel routing logic, routing of data signals between the active bus lanes and the optical channels so as to remove the failed optical channel from further use and use a spare optical channel instead of the failed optical channel.