Systems, methods, apparatuses, and software for operating a wireless access node are provided herein. In one example, a method includes providing wireless access from the wireless access node for one or more wireless devices using an initial protocol data unit (PDU) size for at least a portion of the wireless access. The method also includes receiving wireless transmission metrics transferred by a second wireless access node, and establishing a new PDU size for the portion of the wireless access at the wireless access node based at least on the wireless transmission metrics.