Methods, systems, and computer readable media for nuisance call management. In one example, a method includes receiving, at a telecommunications signaling computer system for routing telecommunications signaling messages in a core network of a telecommunications signaling network, a message from a subscriber's user equipment (UE) indicating that the subscriber has flagged a first call as a nuisance call. The method includes storing, in a subscriber-level nuisance call database, an association between a calling party identifier for the calling party and a subscriber identifier for the subscriber. The method includes, in response to a second call from the calling party to the subscriber, blocking, at the telecommunications signaling computer system, the second call using the association between the calling party identifier and the subscriber identifier in the subscriber-level nuisance call database.