The present invention relates to a wireless communication system, and more specifically, to a method and an apparatus for enhanced-control channel-based operation. A method for a terminal for transmitting confirmation response information in a wireless communication system according to one embodiment of the present invention comprises a step for transmitting confirmation response information for a downlink data channel by means of an uplink control channel resource, wherein an index for the uplink control channel resource can be determined on the basis of a delegate antenna port of a downlink control channel derived from the identifier of the terminal.