Invention Grant
- Patent Title: Activators of human pyruvate kinase
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Application No.: US14643107Application Date: 2015-03-10
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Publication No.: US09708267B2Publication Date: 2017-07-18
- Inventor: Matthew B. Boxer , Min Shen , Douglas S. Auld , Craig J. Thomas , Martin J. Walsh
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: C07D215/227
- IPC: C07D215/227 ; C07D209/30 ; C07D215/36 ; C07D223/16 ; C07D265/36 ; C07D209/12 ; C07D209/34 ; C07D235/26
Abstract:
Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1-NR-L-A2(I).
Public/Granted literature
- US20150183744A1 ACTIVATORS OF HUMAN PYRUVATE KINASE Public/Granted day:2015-07-02
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