Invention Grant
- Patent Title: Sulfoximine substituted quinazolines for pharmaceutical compositions
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Application No.: US14802235Application Date: 2015-07-17
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Publication No.: US09708274B2Publication Date: 2017-07-18
- Inventor: Andreas Blum , Dirk Gottschling , Armin Heckel , Joerg P. Hehn , Bernhard Schmid , Dieter Wiedenmayer
- Applicant: EVOTEC INTERNATIONAL GMBH
- Applicant Address: DE
- Assignee: EVOTEC INTERNATIONAL GMBH
- Current Assignee: EVOTEC INTERNATIONAL GMBH
- Current Assignee Address: DE
- Agency: J.A. Lindeman & Co., PLLC
- Priority: EP13174337 20130628
- Main IPC: C07D239/94
- IPC: C07D239/94 ; C07D413/14 ; A61K31/517 ; C07D409/12 ; C07D401/12 ; C07D413/12 ; C07D411/12 ; C07D409/14 ; C07D495/10 ; C07D403/12 ; A61K45/06 ; A61K31/541 ; C07D401/14 ; C07D405/12 ; C07D417/04 ; C07D417/14 ; A61K31/5377
Abstract:
This invention relates to novel sulfoximine substituted quinazoline derivatives of formula I wherein Ar, R1 and R2 are as defined in the description and claims, and their use as MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) mediated disorders.
Public/Granted literature
- US20150361055A1 SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS Public/Granted day:2015-12-17
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