![Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl)-(2-chlorophenyl)-methanone](/docs/US/2017-07-18/US09708291B2/abs.jpg.600x600.jpg)
- Patent Title: Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl)-(2-chlorophenyl)-methanone
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Application No.: US14937051Application Date: 2015-11-10
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Publication No.: US09708291B2Publication Date: 2017-07-18
- Inventor: Michael Edward Kobierski , Michael E. Kopach , Pingyun Chen
- Applicant: Eli Lilly and Company
- Applicant Address: US DC Washington
- Assignee: Vanda Pharmaceuticals Inc.
- Current Assignee: Vanda Pharmaceuticals Inc.
- Current Assignee Address: US DC Washington
- Agency: Hoffman Warnick LLC
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D401/06 ; C07D213/53 ; C07D213/50
![Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl)-(2-chlorophenyl)-methanone](/abs-image/US/2017/07/18/US09708291B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
Public/Granted literature
- US20160060250A1 NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE Public/Granted day:2016-03-03
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