Invention Grant
- Patent Title: Flouro-naphthyl derivatives
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Application No.: US15216435Application Date: 2016-07-21
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Publication No.: US09708302B2Publication Date: 2017-07-18
- Inventor: Katrin Groebke Zbinden , Emmanuel Pinard , Thomas Ryckmans
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: HOFFMANN-LA-ROCHE INC.
- Current Assignee: HOFFMANN-LA-ROCHE INC.
- Current Assignee Address: US NJ Little Falls
- Agency: Genentech, Inc.
- Agent Mark D. Kafka
- Priority: EP14152124 20140122
- Main IPC: C07D405/02
- IPC: C07D405/02 ; C07D405/14 ; C07D213/61 ; C07D213/56 ; C07D309/14 ; C07D401/04 ; C07D405/12

Abstract:
The present invention relates to compounds of formula wherein R1 is C4-6-cycloalkyl or C4-6-heterocycloalkyl, which are optionally substituted by one or two substituents, selected from hydroxy or lower alkyl; A is phenyl, pyridinyl or piperidinyl; R2 is hydrogen, halogen, lower alkyl, cyano, C4-6-cycloalkyl, lower alkoxy, lower alkoxy substituted by halogen, or is a five- or six-membered heteroaryl, optionally substituted by lower alkyl; n is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment or prophylaxis of Alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders.
Public/Granted literature
- US20160326144A1 FLOURO-NAPHTHYL DERIVATIVES Public/Granted day:2016-11-10
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