- Patent Title: Modified microbial toxin receptor for delivering agents into cells
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Application No.: US14625386Application Date: 2015-02-18
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Publication No.: US09708374B2Publication Date: 2017-07-18
- Inventor: Adva Mechaly , Andrew J. McCluskey , R. John Collier
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Tari W. Mills
- Main IPC: A61K39/02
- IPC: A61K39/02 ; A61K39/07 ; A61K39/00 ; C07K14/32 ; C07K16/32 ; C07K14/21 ; C07K14/25 ; C07K14/28 ; C07K14/33 ; C07K14/34 ; C07K16/28 ; C07K16/40
Abstract:
We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell target instead of its natural cell target. The system can be used for, e.g., targeted killing of undesired cells in a population of cells, such as cancer or overly active immune system cells.
Public/Granted literature
- US20160362458A9 MODIFIED MICROBIAL TOXIN RECEPTOR FOR DELIVERING AGENTS INTO CELLS Public/Granted day:2016-12-15
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