Invention Grant
- Patent Title: Nucleic acids encoding polypeptides which disrupt D1-D2 dopamine receptor coupling and modulate function
-
Application No.: US14996354Application Date: 2016-01-15
-
Publication No.: US09708385B2Publication Date: 2017-07-18
- Inventor: Fang Liu , Lin Pei
- Applicant: Centre for Addiction and Mental Health
- Applicant Address: CA Toronto
- Assignee: Centre for Addiction and Mental Health
- Current Assignee: Centre for Addiction and Mental Health
- Current Assignee Address: CA Toronto
- Agency: Brooks Kushman P.C.
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C07K14/47 ; C07K16/28 ; A61K38/00
Abstract:
The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and agents are provided for modulating dopamine receptor function arising from D1-D2 coupling and/or activation. Agents of the present invention include fragments of D2 receptor or D1 receptor that can disrupt D1-D2 coupling.
Public/Granted literature
- US20160237138A1 Polypeptides and Methods For Modulating D1-D2 Dopamine Receptor Interaction and Function Public/Granted day:2016-08-18
Information query
