Invention Grant
- Patent Title: Modified chimeric polypeptides with improved pharmacokinetic properties
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Application No.: US14822929Application Date: 2015-08-11
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Publication No.: US09708386B2Publication Date: 2017-07-18
- Inventor: Nicholas J. Papadopoulos , Samuel Davis , George D. Yancopoulos
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: US NY Tarrytown
- Agent Frank R. Cottingham
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/71 ; C07K16/22 ; C07K19/00 ; A61K38/00
Abstract:
The present invention provides VEGF antagonists with improved pharmacokinetic properties. According to certain embodiments, a fusion polypeptide capable of antagonizing VEGF activity is provided comprising a modified extracellular ligand binding domain of a VEGF receptor fused to a multimerizing component.
Public/Granted literature
- US20160130320A1 MODIFIED CHIMERIC POLYPEPTIDES WITH IMPROVED PHARMACOKINETIC PROPERTIES Public/Granted day:2016-05-12
Information query
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